The sensitivity of sheep to rocuronium

Originally Published hereSheep are a well-established model for cardiovascular research (DiVincenti et al. 2014). Anesthesia for thoracic and cardiac surgery may often include neuromuscular block. It has been shown that sheep are substantially more sensitive to the effects of vecuronium and pancuronium, two steroidal neuromuscular blocking agents, than people and other domestic species like the dog…

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Personalised blood pressure management during major noncardiac surgery and postoperative neurocognitive disorders: a randomised trial

Originally Published hereIt remains unknown whether there is a causal relationship between intraoperative hypotension and postoperative neurocognitive disorders. We tested the hypothesis that personalised—compared to routine—intraoperative blood pressure management reduces the incidence of postoperative neurocognitive disorders in patients having major noncardiac surgery.

Comparison of the effects of intranasal and intramuscular midazolam–butorphanol–ketamine on intraocular pressure, tear production and sedation in New Zealand White rabbits

Originally Published hereTo compare the effects of intranasal (IN) and intramuscular (IM) midazolam–butorphanol–ketamine on intraocular pressure (IOP), tear production (TP) and sedation in rabbits.

Dead space volumes in cats and dogs with small body mass ventilated with a fixed tidal volume

Originally Published hereTo compare the portion of tidal volume (VT) ventilating dead space volumes in nonbrachycephalic cats and dogs with small body mass receiving volume-controlled ventilation (VCV) with a fixed VT.

The impact of using pain scales by untrained students on the decision to provide analgesia to multiple species

Originally Published hereTo evaluate if students without training assess pain similarly to an expert, and to compare indications for analgesic intervention based on student opinions versus scale scoring.

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Changes of pulse wave transit time after haemodynamic manoeuvres in healthy adults: a prospective randomised observational trial (PWTT volunteer study)

Originally Published herePulse wave transit time (PWTT) shows promise for monitoring intravascular fluid status intraoperatively. Presently, it is unknown how PWTT mirrors haemodynamic variables representing preload, inotropy, or afterload.

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Effects of opioid-based versus opioid-free anaesthesia on blinded nociception level index values during laparoscopic gastric bypass surgery: a secondary analysis of a randomised double-blind trial

Originally Published hereEditor—We recently reported the impact of an opioid-free anaesthesia (OFA) strategy, when compared with an opioid-based anaesthesia (OBA) strategy on postoperative morphine consumption and patient comfort during laparoscopic gastric bypass surgery in class III obese patients.1 This study included 172 patients in total and a subgroup was monitored with the Nociception Level Index…

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Efficacy of parasternal peripheral nerve catheters versus no block for median sternotomy: a single-centre retrospective study

Originally Published hereSternal pain after cardiac surgery results in considerable discomfort. Single-injection parasternal fascial plane blocks have been shown to reduce pain scores and opioid consumption during the first 24 h after surgery, but the efficacy of continuous infusion has not been evaluated. This retrospective cohort study examined the effect of a continuous infusion of…